4-Dimethylaminopyridine

DMAP is a useful nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides⁴, the Baylis-Hillman reaction⁵, hydrosilylations, tritylation, the Steglich rearrangement and the Staudinger synthesis of β-lactams. Chiral DMAP analogues are used in kinetic resolution experiments of mainly secondary alcohols and Evans auxilary type amides. ^1,2 DMAP is also used as a coupling agent for the synthesis of peptide and an efficient ligand for the Heck reaction in aqueous media ³.

Reference

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